2021 Louisville Cardinals Cardinal Stadium 6-7 Record First Responders Bowl       Weeks No Louisville Spring Game     photo: @GoCards   vs. Mississippi Monday, September 6, 8:00 et Mercedes-Benz Stadium - Atlanta, GA     photo: Brett Davis   vs. E. Kentucky Saturday, September 11, 7:00 et Cardinal Stadium - Louisville, KY     photo: Mark Blankenbaker   vs. Central Florida Friday, September 17, 7:30 et Cardinal Stadium - Louisville, KY -     photo: Andy Lyons   at Florida State Saturday, September 25, 3:30 et Doak Campbell Stadium - Tallahassee, FL       photo: @UofLFootball   at Wake Forest Saturday, Ocotber 2, 12:30 et Truist Field - Winston-Salem, NC       photo: Reinhold Matay   vs. Virginia Saturday, October 9, 3:00 et Cardinal Stadium - Louisville, KY     photo: Timothy D. Easley bye week       photo: @GoCards   vs. Boston College Saturday, October 23, 4:00 et Cardinal Stadium - Louisville, KY     photo: Timothy D. Easley   at NC State Saturday, October 30, 7:30 et Carter-Finley Stadium - Raleigh, NC     photo: Rob Kinnan   vs. Clemson Saturday, November 6, 7:30 et Cardinal Stadium - Louisville, KY     photo: Jamie Rhodes   vs. Syracuse Saturday, November 13, 12:00 et Cardinal Stadium - Louisville, KY photo: Scott Utterback   at Duke Thursday, November 18, 7:30 et Wallace Wade Stadium - Durham, NC     photo: Jaylynn Nash   vs. Kentucky Saturday, November 27, 7:30 et Cardinal Stadium - Louisville, KY     photo: Jamie Rhodes   vs. Air Force Tuesday, December 28, 2:15 ct Gerald J. Ford Stadium - University Park, TX     photo: Jerome Mirone